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Journal of medicinal chemistry

Synthesis of some N-substituted eleostearic acid hydrazides as potential monoamine oxidase inhibitors

SY Hsu, CL Huang, IW Waters

文献索引:Hsu,S.Y. et al. Journal of Medicinal Chemistry, 1973 , vol. 16, p. 450 - 452

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被引用次数: 0

摘要

The syntheses of five N-substituted eleostearic acid hydrazides are described: N-isopropyl- cu-eleostearoyl hydrazide, N-benzyl*-eleostearo yl hydrazide) N-phenethyl-0-eleostearo yl hydrazide, Nd-methylphenethy 1-0-eleostearoyl hydrazide, and N-0-methylphenethyla- eleostearoyl hydrazide. The compounds were in-vestigated for their ability to inhibit monoamine oxidase in vitro and to elevate the brain monoamines in mice. The results ...