Promiscuity of a modular polyketide synthase towards natural and non-natural extender units

I Koryakina, JB McArthur, MM Draelos…

文献索引：Koryakina, Irina; McArthur, John B.; Draelos, Matthew M.; Williams, Gavin J. Organic and Biomolecular Chemistry, 2013 , vol. 11, # 27 p. 4449 - 4458

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被引用次数: 31

摘要

Combinatorial biosynthesis approaches that involve modular type I polyketide synthases (PKSs) are proven strategies for the synthesis of polyketides. In general however, such strategies are usually limited in scope and utility due to the restricted substrate specificity of polyketide biosynthetic machinery. Herein, a panel of chemo-enzymatically synthesized acyl- CoA's was used to probe the promiscuity of a polyketide synthase. Promiscuity ...