Scandium triflate as an efficient and useful catalyst for the synthesis of β-amino alcohols by regioselective ring opening of epoxides with amines under solvent-free …
AT Placzek, JL Donelson, R Trivedi, RA Gibbs, SK De
文献索引：Placzek, Andrew T.; Donelson, James L.; Trivedi, Rushi; Gibbs, Richard A.; De, Surya K. Tetrahedron Letters, 2005 , vol. 46, # 52 p. 9029 - 9034
A simple and efficient method has been developed for the synthesis of β-amino alcohols by ring opening of epoxides in the presence of a catalytic amount of Sc (OTf) 3 at room temperature under solvent-free conditions. The reaction works well with both aromatic and aliphatic amines. High regio-, and diastereoselectivity can be considered as a noteworthy advantage of this method.
