Synthesis and serotonin 2 (5-HT2) receptor antagonist activity of 5-aminoalkyl-substituted pyrrolo [3, 2-c] azepines and related compounds.

…, A OGATA, T Kamei, M Shibata, T Shimamoto…

文献索引：Mizuno, Akira; Ogata, Atsuto; Kamei, Tomoe; Shibata, Makoto; Shimamoto, Tetsuo; Hayashi, Yasuhiro; Nakanishi, Kyoko; Takiguchi, Chikako; Oka, Naomi; Inomata, Norio Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 5 p. 623 - 635

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被引用次数: 8

摘要

A series of 5-aminoalkylpyrrolo [3, 2-c] azepine derivatives was synthesized and their serotonin 2 (5-HT 2) receptor antagonist and antiplatelet aggregation activities were evaluated. 5-HT 2 receptor antagonist activity was largely determined by the nature of the substituent at the 8-position as well as aminoalkyl group at the 5-position of the pyrrolo [3, 2- c] azepine ring. Compound 18a, 5-[3-] 4-(4-fluorophenyl) piperazin-1-yl] propyl]-8-hydroxy ...