Antianaphylactic benzophenones and related compounds

D Evans, ME Cracknell, JC Saunders…

文献索引：Evans, Delme; Cracknell, Mark E.; Saunders, John C.; Smith, Christine E.; Williamson, W. R. Nigel; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1321 - 1327

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被引用次数: 35

摘要

The synthesis and biological properties of 85 benzophenones and related compounds are described. The majority of the compounds inhibit the release of leukotrienes (LT) C4 and D4 in vitro from sensitized guinea pig chopped lung. In addition, some of the compounds inhibited the release of LTs from passively sensitized human chopped lung and protected guinea pigs from the effects of anaphylaxis in a modified Herxheimer test.