The Journal of organic chemistry

Catalytic coupling of arene C–H bonds and alkynes for the synthesis of coumarins: substrate scope and application to the development of neuroimaging agents

PA Vadola, D Sames

文献索引：Vadola, Paul A.; Sames, Dalibor Journal of Organic Chemistry, 2012 , vol. 77, # 18 p. 7804 - 7814,11

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被引用次数: 30

摘要

C–H bond functionalization offers strategically novel approaches to complex organic compounds. However, many C–H functionalization reactions suffer from poor compatibility with Lewis basic functional groups, especially amines, which are often essential for biological activity. This study describes a systematic examination of the substrate scope of catalytic hydroarylation in the context of complex amino coumarin synthesis. The choice of ...