Synthesis and discovery of highly functionalized mono-and bis-spiro-pyrrolidines as potent cholinesterase enzyme inhibitors

…, H Osman, RS Kumar, A Basiri, V Murugaiyah

文献索引：Kia, Yalda; Osman, Hasnah; Suresh Kumar, Raju; Basiri, Alireza; Murugaiyah, Vikneswaran Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 7 p. 1815 - 1819

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被引用次数: 11

摘要

Abstract Novel mono and bis spiropyrrolidine derivatives were synthesized via an efficient ionic liquid mediated, 1, 3-dipolar cycloaddition methodology and evaluated in vitro for their AChE and BChE inhibitory activities in search for potent cholinesterase enzyme inhibitors. Most of the synthesized compounds displayed remarkable AChE inhibitory activities with IC 50 values ranging from 1.68 to 21.85 μM, wherein compounds 8d and 8j were found to be ...