Synthesis and in vitro characterization of some benzothiazole-and benzofuranone-derivatives for quantification of fibrillar aggregates and inhibition of amyloid- …
Abstract Neurodegenerative diseases are characterized by amyloid deposition. Thioflavin T (ThT) is one of the molecules considered for detection of amyloid deposits; however, its lipophilicity is too low to cross the blood–brain barrier. Therefore, there is a strong motivation to develop suitable compounds for in vitro fibril quantification as well as for in vivo amyloid imaging. Moreover, oxidative stress (particularly, uncontrolled peroxidase activity) has ...
