As a consequence of the tremendous recent interest in the derivatives of 8-aminoquinoline as antimalarial drugs it was found desirable to develop a satisfactory synthesis for 8-amino- 2, 4-dimethylquinoline. The present procedure was found to be a rapid and efficient method for the preparation of this substance, one of its advantages being that it obviates any extensive purification of the intermediate 8-nitro-2, 4-dimethylquinoline.
