Novel approach to nucleoside-5′-(1-hydroxymethylene-1, 1-bisphosphonates): synthesis of new AZT analogues

…, M Monteil, P Even, M Lecouvey

文献索引：Migianu, Evelyne; Monteil, Maelle; Even, Pascale; Lecouvey, Marc Nucleosides, Nucleotides and Nucleic Acids, 2005 , vol. 24, # 2 p. 121 - 133

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被引用次数: 6

摘要

An efficient synthetic method of nucleoside-5′-(1-hydroxymethylene-1, 1-bisphosphonates) is reported here. The procedure was optimized with 3′-protected thymidine and then applied to synthesis of new AZT analogues. We thank Pr. J. Liquier from the Laboratoire de Chimie Structurale Biomoléculaire (UMR 7033-CNRS, Bobigny, France) for IR spectra, the Laboratoire de Biochimie des Protéines et Protéomique (UPRES EA 3408, Bobigny, ...