Nucleosides, Nucleotides and Nucleic Acids

Bicyclic Nucleoside Synthesis—A Photochemical Approach

E Lee-Ruff, D Wells

文献索引：Lee-Ruff; Wells Nucleosides, Nucleotides and Nucleic Acids, 2008 , vol. 27, # 5 p. 484 - 494

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被引用次数: 4

摘要

The synthesis of a series of bicyclic nucleosides using photolytic ring-expansion of cyclobutanones is reported. The cyclobutanone precursors were prepared by [2+ 2] cycloaddition of a series of cyclic alkenes with chlorinated ketenes, derived from dichloro- and trichloroacetyl chloride. The synthesis of the nucleosides was achieved through photolysis of cyclobutanone precursors with 6-chloropurine by UV irradiation. The ...