Syntheses and adrenergic agonist properties of ring-fluorinated isoproterenols

…, D Cantacuzene, B Collins, GT Chen…

文献索引：Kirk; Cantacuzene; Collins; Chen; Nimit; Creveling Journal of Medicinal Chemistry, 1982 , vol. 25, # 6 p. 680 - 684

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被引用次数: 24

摘要

2-Fluoro-, S-flUOrO-, and 6-fluoroisoproterenol were synthesized by reduction of the Schiff base formed between the corresponding ring-fluorinated 3, 4-bis (benzyloxy) phenethanolamine and acetone, followed by reductive debenzylation in the presence of oxalic acid to yield crystalline neutral oxalates. The apparent 0-adrenergic potencies were determined in the isolated guinea pig atria. 2-Fluoro-and 5-fluoroisoproterenol were ...