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Journal of medicinal chemistry

Perfluoroalkyl carbonyl compounds. 2. Derivatives of hexafluoroacetone

SS Szinai, G Crank, DRK Harding

文献索引:Crank,G. et al. Journal of Medicinal Chemistry, 1970 , vol. 13, p. 1215 - 1217

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被引用次数: 26

摘要

E'ollowing our work on the perfluoroalkyl aldehydes' we now present a study of hexafluoroacetone. The objective was the examination of the biological properties of masked hexafluoroacetone (HFA), and as a consequence some simple derivatives of the ketone, with limited stability have been synthesised. The arguments presented in part 1'for this approach are also relevant to the present study.