N-hydroxy amides. III. Active esters of polystyrene-bound 1-hydroxy-2-pyrrolidinone and their use in peptide synthesis.

M Akiyama, K Shimizu, S Aiba, H Katoh

文献索引：Akiyama, Masayasu; Shimizu, Kazuyuki; Aiba, Seiichi; Katoh, Hiroaki Bulletin of the Chemical Society of Japan, 1985 , vol. 58, # 5 p. 1421 - 1425

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被引用次数: 12

摘要

A polymer-bond cyclic N-hydroxy amide has been prepared by reaction of aminomethylated copoly (styrene–2% divinylbenzene) with 1-hydroxy-5-oxo-3-pyrrolidinecarboxylic acid using dicyclohexylcarbodiimide (DCC) as a condensing agent. Several N-blocked α-amino acids have been loaded on this resin by use of DCC. The amino acid resin can be utilized for peptide synthesis. Repetitive usage of the resin in the form of esters and facile ...