The Journal of Organic Chemistry

Synthesis and properties of 7-alkoxyfurazano [3, 4-d] pyrimidines and their use in the preparation of 4-alkoxypteridines and N3-substituted pterins

PH Boyle, RJ Lockhart

文献索引：Boyle, Peter H.; Lockhart, Ronan J. Journal of Organic Chemistry, 1985 , vol. 50, # 25 p. 5127 - 5132

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被引用次数: 11

摘要

Like other furazano [3, 4-d] pyrimidines which have been studied, 3~~,~ the 7-&oxy compounds 5 and 6, and also 8-10, suffered ready hydrogenolysis of the furazan ring when stirred with a palladized charcoal catalyst in methanol or aqueous methanol solution under an atmosphere of hydrogen (Scheme 11). The resulting 6-alkoxy-2, 4, 5-triaminopyrimidines were labile to air in the form of their free bases. Compounds 14-16, however, were ...