Sulfonamides Acting on the Central Nervous System, VI

A Monzani, G Gamberini, D Braghiroli…

文献索引：Monzani; Gamberini; Braghiroli; Di Bella; Raffa; Sandrini Archiv der Pharmazie, 1985 , vol. 318, # 4 p. 299 - 304

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摘要

Abstract A series of 2-(acylamino) benzenesulfonamides was prepared. Their anti- convulsant effects on two convulsives (electro-shock and pentetrazol) were studied. The structure/effect relationships were compared with those of a series of isomeric 2- aminobenzenesulfon-N-acylamides and of 2-nitrobenzenesulfon-N-acylamides. The possible influence of pK a and log P was examined.