Imidazo [1, 2-a] pyrimidines and imidazo [1, 2-a] pyrazines: the role of nitrogen position in inotropic activity

WA Spitzer, F Victor, GD Pollock…

文献索引：Spitzer, Wayne A.; Victor, Frantz; Pollock, G. Don; Hayes, J. Scott Journal of Medicinal Chemistry, 1988 , vol. 31, # 8 p. 1590 - 1595

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被引用次数: 51

摘要

Several years ago Fisher and Lusi6 demonstrated a similarity of structure-activity relationships between benzimidazole anthelmintics and their corresponding [1, 2-a]-pyridine counterparts. This correlation has been extended by Bochis et aL7 Thus, benzimidazoles A and corresponding [1, 2-a] pyridines B (see Figure 1) have similar anthelmintic activity.