Abstract By reaction of 6-[N-(2-hydroxyethyl)-N-methyl] aminopurine (2a) and of the corresponding 3-hydroxypropyl derivative 2b with thionyl chloride a bridge to N (1) is formed yielding 5 and 6, respectively, whereas from 6-[N-(4-hydroxybutyl)-N-methyl] aminopurine (2c) the 4-chlorobutyl compound 4 is obtained, which cyclizes in alkaline medium to the C (6)-N (7) bridged compound 7. A related cyclization to 11a–11f is observed when 6- ...
