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First general solvent??free synthesis of symmetrical triindolylmethanes using acid??washed montmorillonite clay

M Chakrabarty, S Sarkar, A Linden…

文献索引:Chakrabarty, Manas; Sarkar, Sandipan; Linden, Anthony; Stein, Bridget K. Synthetic Communications, 2004 , vol. 34, # 10 p. 1801 - 1810

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被引用次数: 18

摘要

Abstract Dry reaction of indoles and alkylindoles (1a–h) with triethyl orthoformate (2.5 equiv.) on acid??washed montmorillonite K10 clay at room temperature afforded in< 5 min–4 hr the respective symmetrical TIMs (2a–h) in good to high yields along with the formylindole 3 and the formyl??TIM 4 from 1g and 1h, respectively.