An expedient synthesis of LAF389, a bengamide B analogue

…, K Prasad, O Repič, TJ Blacklock

文献索引：Liu, Wenming; Xu, David D.; Repic, Oljan; Blacklock, Thomas J. Tetrahedron Letters, 2001 , vol. 42, # 13 p. 2439 - 2441

全文：HTML全文

被引用次数: 29

摘要

An optimized, convergent, safe synthesis of LAF389 (9), an anti-cancer agent analogous to bengamide B, is described. Starting from α-d-glucoheptonic (d-glycero-d-gulo-heptonic acid) γ-lactone (10), the lactone 15 was constructed in five steps. Major improvements were made