Medicinal Chemistry Research

Synthesis and anticancer activity evaluation of new 1, 2, 3-triazole-4-carboxamide derivatives

N Pokhodylo, O Shyyka, V Matiychuk

文献索引：Pokhodylo, Nazariy; Shyyka, Olga; Matiychuk, Vasyl Medicinal Chemistry Research, 2014 , vol. 23, # 5 p. 2426 - 2438

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被引用次数: 12

摘要

Abstract Anticancer screening of several novel 1, 2, 3-triazoles has been performed. The 1, 2, 3-triazole derivatives were synthesized from available starting materials according to the convenient synthetic procedures using a multicomponent reaction which gave a wide access to triazole derivatives production. The synthesized compounds were tested for their anticancer activity in NCI60 cell lines. It was observed that some compounds showed ...