Conjugation chemistry through acetals toward a dextran-based delivery system for controlled release of siRNA
…, PR Wich, PH Kierstead, JMJ Fréchet
文献索引：Cui, Lina; Cohen, Jessica L.; Chu, Crystal K.; Wich, Peter R.; Kierstead, Paul H.; Frechet, Jean M. J. Journal of the American Chemical Society, 2012 , vol. 134, # 38 p. 15840 - 15848,9
New conjugation chemistry for polysaccharides, exemplified by dextran, was developed to enable the attachment of therapeutic or other functional moieties to the polysaccharide through cleavable acetal linkages. The acid-lability of the acetal groups allows the release of therapeutics under acidic conditions, such as that of the endocytic compartments of cells, regenerating the original free polysaccharide in the end. The physical and chemical ...
