Highly efficient desilylation of 3-trimethylsilylprop-2-ynamides by the action of KF-Al2O3

MV Andreev, LP Safronova, AS Medvedeva

文献索引：Andreev; Safronova; Medvedeva Russian Journal of Organic Chemistry, 2011 , vol. 47, # 12 p. 1797 - 1801

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被引用次数: 2

摘要

Abstract A highly effective procedure has been developed for desilylation of 3- trimethylsilylprop-2-ynamides in the presence of KF-Al 2 O 3 as catalyst. The corresponding terminal prop-2-ynamides were obtained in high yield in methanol at 25° C using 5 mol% of the catalyst (reaction time 20 min). Rise in temperature leads to the formation of Z, E-3- methoxyprop-2-enamides or 3, 3-dimethoxypropanamides as a result of tandem ...