Bioorganic & medicinal chemistry

Synthesis and antitumor activity of C-9 epimers of the tetrahydrofuran containing acetogenin 4-deoxyannoreticuin

F Wang, A Kawamura, DR Mootoo

文献索引：Wang, Feng; Kawamura, Akira; Mootoo, David R. Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 18 p. 8413 - 8418

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被引用次数: 8

摘要

A highly convergent synthesis of mono-tetrahydrofuran (THF) containing acetogenins, that is based on the cross-metathesis of THF and butenolide alkene precursors, was developed. This methodology was applied to the epimers of the C-9 alcohol of 4-deoxyannoreticuin, in an attempt to assign the configuration at this position in the naturally occurring material. Unfortunately, identification of one or the other epimeric structures with the natural product ...