Tetrahedron Letters

Positional chemoselectivity in the Zn (II)-mediated removal of phenol protecting groups

LM Fleury, JB Gianino, BL Ashfeld

文献索引：Fleury, Lauren M.; Gianino, Joseph B.; Ashfeld, Brandon L. Tetrahedron Letters, 2012 , vol. 53, # 40 p. 5376 - 5379

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被引用次数: 1

摘要

A protocol was developed for the chemoselective ortho-deprotection of polyphenolic substrates using readily available ZnIIX2 salts. This procedure provides exceptional positional selectivity for the deprotection of phenols that reside adjacent to directing carbonyl functionality in the presence of similar protecting groups at the meta and para positions. Good to excellent yields of the desired free phenols were obtained (⩽ 96%), and a wide ...