2-(4-Chlorophenyl)-2-oxoethyl 4-benzamidobenzoate derivatives, a novel class of SENP1 inhibitors: Virtual screening, synthesis and biological evaluation

…, D Wen, Z Huang, M Huang, Y Luo, B Liu, H Lu…

文献索引：Chen, Yingyi; Wen, Donghua; Huang, Zhimin; Huang, Min; Luo, Yu; Liu, Bin; Wu, Yingli; Zhang, Jian; Lu, Han; Peng, Yuefeng Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 22 p. 6867 - 6870,4

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被引用次数: 13

摘要

Prostate cancer is one of the most prevalent types of malignant cancers in men and has a high mortality rate among all male cancers. Previous studies have demonstrated that Sentrin/SUMO-specific protease 1 (SENP1) plays an important role in the occurrence and development of prostate cancer, and has been identified as a novel drug target for development of small molecule drugs against prostate cancer. In this paper, we used ...