The design of magnetic resonance contrast agents: new iron (III) dihydroxamate complexes

…, A Gref, J Courtieu, AL Crumbliss, A Gaudemer…

文献索引：Chaubet, Frederic; Nguyen Van Duong, Marguerite; Gref, Aurore; Courtieu, Jacques; Crumbliss, Alvin L.; Gaudemer, Alain Tetrahedron Letters, 1990 , vol. 31, # 40 p. 5729 - 5732

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被引用次数: 6

摘要

Abstract We have prepared a series of dihydroxamates and their iron (III) complexes in view of obtaining new NMR imaging agents. Four new dihydroxamic acid ligands have been synthesized by condensation of 4-substituted-2, 6-pyridine dicarboxylic acids with N- aminopropyl-N-acetylhydroxylamine, and the iron (III) complexes exhibit high stability over the pH range 3 to 7 and a binuclear structure Fe 2 L 3 at pH 7. The presence of two non- ...