Esters and lactones of phenolic amino carboxylic acids. Prodrugs for iron chelation

…, J Thompson, MC Wani, H Rosenkrantz…

文献索引：Pitt, C. G.; Bao, Y.; Thompson, J.; Wani, M. C.; Rosenkrantz, H.; Metterville, J. Journal of Medicinal Chemistry, 1986 , vol. 29, # 7 p. 1231 - 1237

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被引用次数: 51

摘要

Results Chemical Synthesis. Compound 1 was prepared by sequential alkylation of o- anisidine with 1, Zdibromoethane and then methyl a-bromoacetate. The lactones of 1 and 3 were prepared by treatment of the carboxylic acids with thionyl chloride. Esters of 5 were prepared by treatment of the carboxylic acids with thionyl chloride in the presence