A general synthetic method of 5-carboranyluracil nucleosides with potential antiviral activity and use in neutron capture therapy
…, YA El-Kattan, X Xia, J McAtee, J Soria…
文献索引：Goudgaon, Naganna M.; El-Kattan, Yahya A.; Xia, Xiaoyang; McAtee, Jeff; Soria, Jose; Wey, Shiow-Jyi; Liotta, Dennis C.; Schinazi, Raymond F. Nucleosides and Nucleotides, 1997 , vol. 16, # 12 p. 2133 - 2150
Abstract Previous biochemical and pharmacological studies indicated that 5-o-carboranyl- 2′-deoxyuridine is a lead candidate for boron neutron capture therapy. This prompted the development of a rapid and stereoselective N 1-glycosylation reaction of silylated 5-o- carboranyluracil with a variety of protected sugars. The key intermediate, 5-o- carboranyluracil (6), was prepared from 5-iodouracil in six steps. A novel coupling ...
