The Chemistry of Pseudomonic Acid. 15. 1 Synthesis and Antibacterial Activity of a Series of 5-Alkyl, 5-Alkenyl, and 5-Heterosubstituted Oxazoles

P Brown, DT Davies, PJ O'Hanlo…

文献索引：Brown, Pamela; Davies, David T.; O'Hanlon, Peter J.; Wilson, Jennifer M. Journal of Medicinal Chemistry, 1996 , vol. 39, # 2 p. 446 - 457

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被引用次数: 34

摘要

The synthesis of a range of 5-alkyl, 5-alkenyl, and 5-heterosubstituted 2-(1-normon-2-yl) oxazoles is described. The antibacterial activity was determined as the minimum inhibitory concentration against a range of Gram-positive and Gram-negative organisms using a standard Agar dilution procedure. Compounds possessing an acid functionality directly on, or close to, the ring were found to be of greatly decreased potency, while increasing ...