Tetrahedron

Biosynthesis of tylophorine and tylophorinine

DS Bhakuni, VK Mangla

文献索引：Bhakuni, Dewan S.; Mangla, Virendra K. Tetrahedron, 1981 , vol. 37, p. 401 - 407

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被引用次数: 24

摘要

Administration of 3, 4-dihydroxyphenyl [2-14C] alanine to young Tylophora asthmatica plants revealed that ring B and carbon atoms C9 and C7 of tylophorine and tylophorinine are derived from dopa. Tracer experiments with 6, 7-diphenylhexahydroindolizines (1–7) and (26) demonstrated that compound 1 is efficiently and specifically incorporated into tylophorine (13) and tylophorinine (16). Compounds (3),(4) and (26) were not metabolized ...