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Journal of medicinal chemistry

Synthesis, biological evaluation, and preliminary structure-activity considerations of a series of alkylphenols as intravenous anesthetic agents

R James, JB Glen

文献索引:James, Roger; Glen, John B. Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1350 - 1357

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被引用次数: 136

摘要

Following our discovery of the intravenous (iv) anesthetic activity of 2, 6-diethylphenol in mice, a series of alkylphenols was examined in this species and the most active analogues were further evaluated in rabbits. The synthesis of compounds which were not commercially available was accomplished by adaptations of standard ortho-alkylation procedures for phenols. Structure-activity relationships were found to be complex, but, in general, ...