Abstract Pyranochromenone derivatives 3a–d, 6a–j and 2 H-chromenones 8a–b were synthesized and screened for their in vitro α-amylase inhibitory and ABTS•+[2, 2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid)] free radical scavenging activities. Compounds 3a, 3c, and 6d displayed dual function of ABTS•+ radical scavenging as well as α-amylase inhibition. Compound 6h was found to be most potent α-amylase inhibitor in present ...