… ) phenols, a new class of saluretic agents. 2. Synthesis and pharmacological properties of the 5-aza isostere of 2-(aminomethyl)-4-(1, 1-dimethylethyl)-6-iodophenol
Recently, we reported2 on a series of 2-(aminomethyl)-phenols which were shown to possess a high order of diuretic activity in rats and dogs. It was shown that the molecular features essential for activity are (1) a hydrogen, methyl, or methoxyl group in the 3 position;(2) a halo or C3-C4 a-branched alkyl substituent in the 4 position;(3) a hydrogen, lower alkyl, or lower alkoxy moiety in the 5 position; and (4) a chloro, bromo, or iodo group ...
