Design and synthesis of heterocyclic hydroxamic acid derivatives as inhibitors of Helicobacter pylori urease

…, H Mishra, MA Avery, JS Williamson

文献索引：Muri, Estela Maris F.; Mishra, Hetal; Avery, Mitchell A.; Williamson, John S. Synthetic Communications, 2003 , vol. 33, # 12 p. 1977 - 1995

全文：HTML全文

被引用次数: 25

摘要

Abstract Helicobacter pylori produces ammonia to help counter the acidic environment in the human stomach. The production of ammonia, essential for the microorganism's survival and virulence, is the product of enzymatic conversion of urea by the H. pylori's urease. Inhibition of urease activity by dipeptide hydroxamic acids has previously been demonstrated using a variety of fluorides, thiols and hydroxamic acids. Studies employing computer-aided drug ...