Garcinia xanthones as orally active antitumor agents

…, X Liu, S Zhang, Y Wang, Y Yang, S Zeng…

文献索引：Zhang, Xiaojin; Li, Xiang; Sun, Haopeng; Wang, Xiaojian; Zhao, Li; Gao, Yuan; Liu, Xiaorong; Zhang, Shenglie; Wang, Yanyan; Yang, Yingrui; Zeng, Su; Guo, Qinglong; You, Qidong Journal of Medicinal Chemistry, 2013 , vol. 56, # 1 p. 276 - 292

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被引用次数: 29

摘要

Using a newly developed strategy whose key step is the regioselective propargylation of hydroxyxanthone substrates, 99 structurally diverse Garcinia natural-product-like xanthones based on gambogic acid were designed and synthesized and their in vitro antitumor activity was evaluated. A set of 40 related compounds was chosen for determination of their physicochemical properties including polar surface area, log D 7.4, aqueous solubility, ...