Synthesis and evaluation of a novel nonsteroidal-specific endothelial cell proliferation inhibitor

…, J Mercure, M Feher, R Dunn-Dufault…

文献索引：Schmidt, Jonathan M.; Tremblay, Gilles B.; Page, Martine; Mercure, Julie; Feher, Miklos; Dunn-Dufault, Robert; Peter, Markus G.; Redden, Peter R. Journal of Medicinal Chemistry, 2003 , vol. 46, # 8 p. 1289 - 1292

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被引用次数: 52

摘要

The identification of agents with specific antiproliferative or cytostatic activity against endothelial cells has significant value for the treatment of pathologies associated with angiogenesis, including solid tumors. Here, we describe a novel substituted dibenzo [b, d] pyran-6-one scaffold, exemplified by structures 9a and 10, and report preliminary in vitro activity data indicating that this scaffold is a promising lead for the development of specific ...