Synthesis and Biological Screening of Novel Indolalkyl Arenes Targeting the Serotonine Transporter

…, H Pessoa??Mahana, P Iturriaga??Vásquez…

文献索引：Ojeda-Gomez, Claudia; Pessoa-Mahana, Hernan; Iturriaga-Vasquez, Patricio; Pessoa-Mahana, Carlos David; Recabarren-Gajardo, Gonzalo; Mendez-Rojas, Claudio Archiv der Pharmazie, 2014 , vol. 347, # 3 p. 174 - 184

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摘要

A series of functionalized indolylalkylarenes 3–16 (a and b) were synthesized and their affinities for the serotonin transporter were investigated in vitro. Compounds 3–12 (a and b) were obtained by nucleophilic substitution of 3-(1H-indol-3-yl) propyl-4- methylbenzenesulfonates 2 (a and b) with a series of azaheterocycles. Compounds 14–16 (a and b) were prepared in a two-step sequence by reaction of 3-(1H-indol-3-yl)-2- ...