Development and preclinical studies of broad-spectrum anti-HIV agent (3′ R, 4′ R)-3-cyanomethyl-4-methyl-3′, 4′-di-O-(S)-camphanoyl-(+)-cis-khellactone (3- …
In prior investigation, we discovered that (3′ R, 4′ R)-3-cyanomethyl-4-methyl-3′, 4′-di- O-(S)-camphanoyl-(+)-cis-khellactone (4, 3-cyanomethyl-4-methyl-DCK) showed promising anti-HIV activity. In these current studies, we developed and optimized successfully a practical 10-step synthesis for scale-up preparation to increase the overall yield of 4 from 7.8% to 32%. Furthermore, compound 4 exhibited broad-spectrum anti-HIV activity against ...
