Unprecedented Consecutive, Competitive Nucleophilic Addition to Construct Densely Functionalized Propargylic Alcohols

…, Y An, YH Wang, HY Jiang, YX Zhang…

文献索引：Liu, Jie; An, Yan; Wang, Ya-Hui; Jiang, Hai-Ying; Zhang, Yu-Xin; Chen, Zili Chemistry - A European Journal, 2008 , vol. 14, # 30 p. 9131 - 9134

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摘要

Tandem CÀC bond formation through consecutive nucleophilic addition to construct organic compounds is one of the most attractive strategies in organic synthesis.[1] The classical route, as exemplified by the reaction shown in Scheme1 (top), provides an efficient approach to introduce both α, β substituents at the enone or at an α, β-unsaturated ester. The key intermediate (enolate A) acts as the new nucleophile in the last step.[2] Herein we ...