. alpha.-Methyldopamine derivatives. Synthesis and pharmacology

RJ Borgman, MR Baylor, JJ McPhillips…

文献索引：Borgman,R.J. et al. Journal of Medicinal Chemistry, 1974 , vol. 17, p. 427 - 430

全文：HTML全文

被引用次数: 20

摘要

Several labile, lipophilic analogs of a-methyldopamine were synthesized and evaluated pharmacologically for dopamine-receptor activation and potential anti-Parkinson activity. The compounds were synthesized by selective 0-acetylation and N-alkylation procedures. Compound 10 showed dopamine-receptor stimulating properties and was able to antagonize oxotremorine-induced inhibition of motor activity. These findings are ...