Studies of crystalline vitamin B1. XVII. Synthesis of vitamin B1

JK Cline, RR Williams, J Finkelstein

文献索引：Cline et al. Journal of the American Chemical Society, 1937 , vol. 59, p. 1052

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被引用次数: 35

摘要

&dimethyl-6-aminopyrimidine, 2-methyl-6-oxypyrimidine-5-methylene sulfonic acid3 and the mode of linkage of the two nuclei indicated by the presence of quaternary nitrogen in the vitaminI4 a synthesis of the vitamin was undertaken. The possibilities of three principal routes of synthesis leading to the pyrimidine portion of the vitamin were explored:(1) the addition of formaldehyde to the 5-position of an appropriate pyrimidine;(2) a Curtius, ...