Chemistry–A European Journal

Isocyanide??Based Multicomponent Reactions: Concise Synthesis of Spirocyclic Oxindoles with Molecular Complexity by Using a [1, 5]??Hydrogen Shift as the Key Step

S Su, C Li, X Jia, J Li

文献索引：Su, Shikuan; Li, Chunju; Jia, Xueshun; Li, Jian Chemistry - A European Journal, 2014 , vol. 20, # 20 p. 5905 - 5909

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被引用次数: 21

摘要

Abstract A concise multicomponent reaction of isocyanide, α-substituted allenoate, and methyleneindolinone has been disclosed. This protocol provides a fast and straightforward approach to synthesize unusual tricyclic oxindoles in an efficient and atom-economic manner. Mechanistically, the present cycloaddition may proceed through a cascade sequence involving double Michael addition, double cyclization, double [1, 5]-hydrogen ...