Tetrahedron letters

Enzyme-catalyzed asymmetrization of 2, 2-disubstituted 1, 3-propanediols using 1-ethoxyvinyl esters

S Akai, T Naka, Y Takebe, Y Kita

文献索引：Akai, Shuji; Naka, Tadaatsu; Takebe, Yasushi; Kita, Yasuyuki Tetrahedron Letters, 1997 , vol. 38, # 24 p. 4243 - 4246

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被引用次数: 23

摘要

The lipase-catalyzed asymmetrization of the prochiral 2, 2-disubstituted 1, 3-propanediols 1, 6, and 9 was studied using various types of 1-ethoxyvinyl esters 2. Among them, the use of the benzoate 2f provided good chemical and optical yields of the products 3, 7, and 10 bearing chiral quaternary carbon centers which are fairly stable against racemization.