Synthesis and pharmacological evaluation of derivatives structurally related to nimesulide

G Cignarella, P Vianello, F Berti, G Rossoni

文献索引：Cignarella; Vianello; Berti; Rossoni European Journal of Medicinal Chemistry, 1996 , vol. 31, # 5 p. 359 - 364

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被引用次数: 24

摘要

The present work reports the synthesis of a series of compounds structurally related to the antiinflammatory and antihistaminic agent nimesulide (I), in which the p-nitrophenyl moiety has been replaced by pyridine (1a-c) and pyridine N-oxide (2a-c). In addition, two compounds (3a, 4a) have been synthesized in which the p-nitro group of I was substituted by a cyano and a iH-tetrazol-5-yl group, respectively. Representative 1a and 2a were also ...