New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease

…, R El Achab, J Morral, D Muñoz-Torrero…

文献索引：Camps, Pelayo; El Achab, Rachid; Font-Bardia, Merce; Goerbig, Diana; Morral, Jordi; Munoz-Torrero, Diego; Solans, Xavier; Simon, Montserrat Tetrahedron, 1996 , vol. 52, # 16 p. 5867 - 5880

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被引用次数: 162

摘要

Several new 12-amino-6, 7, 10, 11-tetrahydro-7, 11-methanocycloocta [b] quinoline derivatives (tacrine-huperzine A hybrids, huprines) have been synthesized and tested as acetylcholinesterase (AChE) inhibitors. All of the new compounds contain either a methyl or ethyl group at position 9 and one or two (chloro, fluoro, or methyl) substituents at positions 1, 2, or 3. Among the monosubstituted derivatives, the more active are those substituted at ...