Antiproliferative properties of polyamine analogs: A structure-activity study

RJ Bergeron, JS McManis, CZ Liu, Y Feng…

文献索引：Bergeron, Raymond J.; McManis, James S.; Liu, Charles Z.; Feng, Yang; Weimar, William R.; et al. Journal of Medicinal Chemistry, 1994 , vol. 37, # 21 p. 3464 - 3476

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被引用次数: 145

摘要

A basis set of polyamine analogues was designed and synthesized. These compounds were used to initiate a systematic investigation of the role of chain length, terminal nitrogen alkyl group size, and symmetry of the methylene backbone in the antineoplastic properties of polyamine analogues. New synthetic methods predicated on our earlier polyamine fragment synthesis are described for accessing the tetraamines of interest. An unsymmetrically ...