Phenethyl pyridines with non-polar internal substitutents as selective ligands for estrogen receptor beta

…, BS Katzenellenbogen, JA Katzenellenbogen

文献索引：Waibel, Michael; Kieser, Karen J.; Carlson, Kathryn E.; Stossi, Fabio; Katzenellenbogen, Benita S.; Katzenellenbogen, John A. European Journal of Medicinal Chemistry, 2009 , vol. 44, # 9 p. 3560 - 3570

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被引用次数: 6

摘要

To create estrogen receptor beta (ERβ)-selective ligands with improved biological characteristics, we have extended our investigations of structurally simple bibenzyl-core ligands by preparing a series of compounds in which one phenol is replaced by a 3- hydroxypyridine ring. These phenethyl pyridines were obtained by picoline anion alkylation, and compounds with different patterns of alkyl substitution on the central two carbon units ...