Journal of medicinal chemistry

The 2-Thiopseudourea [ILL], a New Local Anesthesiophore

BM Regan, FT Galysh, RN Morris

文献索引：Regan,B.M. et al. Journal of Medicinal Chemistry, 1967 , vol. 10, p. 649 - 652

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被引用次数: 12

摘要

Twenty 2-thiopseudoureas and related 2-aminothiazoles are shown to be four-to twentyfold more siirface anesthetic and two-to sixfold more anesthetic by infiltration in guinea pigs than lidocaine hydrochloride. Although most of the tabulated 2-thiopseudoureas are more toxic than lidocaine, nevertheless, 19 of them have substantially greater margins of safety (RA/RT= 1.3-2.8). A higher degree of anesthesiophoric specificity is noted for the 2- ...