Tetrahedron letters

An atom efficient and solvent-free synthesis of structurally diverse amides using microwaves

E Gelens, L Smeets, LAJM Sliedregt, BJ van Steen…

文献索引：Gelens, Edith; Smeets, Luc; Sliedregt, Leo A.J.M.; Van Steen, Bart J.; Kruse, Chris G.; Leurs, Rob; Orru, Romano V.A. Tetrahedron Letters, 2005 , vol. 46, # 21 p. 3751 - 3754

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被引用次数: 64

摘要

An array of structurally diverse amides was synthesized efficiently by combining (primary and secondary) amines and carboxylic acids in one-pot under solvent-free microwave (MW) conditions. In most cases, no racemization was observed with optically active inputs and chiral amides were obtained in high ee or de.